Kruppel-Like Factors in Thrombosis and Hemostasis

Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis

Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years support a significant role for this family of transcription factors in carcinogenesis. KLFs can both activate and repress genes that participate in cell-cycle re...

Advances in Thrombosis and Hemostasis

Hemostasis, the arrest of bleeding, requires a finely tuned balance between clot formation and clot degradation. Platelets provide the first line of defense when vascular integrity is compromised. They home to the site of injury where they adhere to the damaged vessel wall, become activated and aggregate to form a platelet plug. The second line of defense involves the strengthening and stabiliz...

Thrombosis and Hemostasis

We recently demonstrated that blockade of the platelet adhesion receptor glycoprotein (GP) Ib protects mice from ischemic stroke. Although von Willebrand factor (VWF) is the major ligand for GPIb , GPIb can engage other counterreceptors on endothelial cells, platelets, and leukocytes (eg, Mac-1 or P-selectin) potentially involved in stroke outcome. To further analyze whether VWF is of particula...

Thrombosis and Hemostasis

1Inserm, Unite 872, Centre de recherche des Cordeliers, Paris, France; 2Université Pierre et Marie Curie-Paris 6, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; 3Université Paris Descartes, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; and 4Department of Drug Discovery and Development, Italian Institute of Technology, Geno...

[Hemostasis and thrombosis].